P441Defective SR-mitochondria interaction and Ca2+ transfer in aged mouse cardiomyocytes
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چکیده
منابع مشابه
Ca2+ removal mechanisms in mouse embryonic stem cell-derived cardiomyocytes.
In mammalian adult cardiomyocytes, sarcoplasmic reticulum (SR) Ca(2+)-ATPase (SERCA) plays a major role in controlling the decline of cytosolic free Ca(2+) concentration ([Ca(2+)](i)) in comparison with sarcolemmal Na(+)/Ca(2+) exchanger (NCX). However, the functional importance of SERCA and NCX in cytosolic Ca(2+) removal during early cardiomyogenesis is still debated. In this study, the funct...
متن کاملMitochondrial uncoupling downregulates calsequestrin expression and reduces SR Ca2+ stores in cardiomyocytes.
AIMS Mitochondrial cardiomyopathy is associated with deleterious remodelling of cardiomyocyte Ca(2+) signalling that is partly due to the suppressed expression of the sarcoplasmic reticulum (SR) Ca(2+) buffer calsequestrin (CASQ2). This study was aimed at determining whether CASQ2 downregulation is directly caused by impaired mitochondrial function. METHODS AND RESULTS Mitochondrial stress wa...
متن کاملSerotonin increases L-type Ca2+ current and SR Ca2+ content through 5-HT4 receptors in failing rat ventricular cardiomyocytes.
Rats with congestive heart failure (CHF) develop ventricular inotropic responsiveness to serotonin (5-HT), mediated through 5-HT(2A) and 5-HT(4) receptors. Human ventricle is similarly responsive to 5-HT through 5-HT(4) receptors. We studied isolated ventricular cardiomyocytes to clarify the effects of 5-HT on intracellular Ca(2+) handling. Left-ventricular cardiomyocytes were isolated from mal...
متن کاملSarcoplasmic reticulum Ca2+‐induced Ca2+ release regulates class IIa HDAC localization in mouse embryonic cardiomyocytes
In embryonic cardiomyocytes, sarcoplasmic reticulum (SR)-derived Ca2+ release is required to induce Ca2+ oscillations for contraction and to control cardiac development through Ca2+ -activated pathways. Here, our aim was to study how SR Ca2+ release regulates cytosolic and nuclear Ca2+ distribution and the subsequent effects on the Ca2+ -dependent localization of class IIa histone deacetylases ...
متن کاملSR Ca2+ refilling upon depletion and SR Ca2+ uptake rates during development in rabbit ventricular myocytes.
While it has been reported that a sparse sarcoplasmic reticulum (SR) and a low SR Ca(2+) pump density exist at birth, we and others have recently shown that significant amounts of Ca(2+) are stored in the neonatal rabbit heart SR. Here we try to determine developmental changes in SR Ca(2+) loading mechanisms and Ca(2+) pump efficacy in rabbit ventricular myocytes. SR Ca(2+) loading (load(SR)) a...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2014
ISSN: 0008-6363,1755-3245
DOI: 10.1093/cvr/cvu091.120